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4 Clinical investigations 3 months of Pycnogenol supplementation in healthy female volunteers (aged 5568) revealed significant increases in hyaluronic acid synthase expression (44%), leading to improved skin hydration and tissue architecture support

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Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression

B12 has also been shown to increase the activity of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which promote nerve survival and regeneration

Plant 5 , 387400 (2012)

By looking closely at formulation design, we can better understand how to support the body without causing unnecessary friction